The Titans are 2-2, but they have allowed more yards than they've gained in three games. The Bills are 3-1 and have not been out-gained in total yardage in a game this season; the Bills are averaging 106 yards per game more than the opposition.
On paper, it appears the wrong team is favored here with the line sitting at the Titans by three. Tennessee is 3-12 against the spread when coming off a double-digit win and facing .750 or fewer opponents, as well as 1-9 against the spread when coming off an NFC foe and facing an opponent coming off a loss.
Buffalo arrives at 4-1 against the spread in games after knocking heads with New England and 9-5 straight up and 10-4 against the spread in games against the AFC South, including 5-0 against the spread against those arriving off a win.
With QB Josh Allen in the concussion protocol, you might have to wait for a decision before placing your money down, but we'll go with the Bills based on the way Allen's health appears to be trending.