Safeties Micah Hyde and Rafael Bush will return to practice Wednesday on a limited basis, Bills coach Sean McDermott said.
Hyde (groin) and Bush (shoulder) did not play in Sunday's victory against Tennessee.
McDermott noted that both players have "made progress" in their recoveries.
The Bills released safety Dean Marlowe on Tuesday after signing quarterback Derek Anderson. Marlowe was elevated from the practice squad to the 53-man roster to play against the Titans with Hyde and Bush sidelined.