Many prognosticators are expecting the Bills to take a step back from a nine-win season and the playoff berth from last season.
If the early odds are any indication, the Bills face an uphill climb.
CG Technology says it is the only sportsbook to release point spreads for all games from Week 1 to Week 16. Many sportsbooks have Week 1 odds.
Virtually none of these lines will be the same by the time game week arrives, but here is where they stand as of today.
The bottom line: The Bills are favored in three games and have two others games listed as pick 'em.
Bills at Baltimore Ravens (-3.5)
Los Angeles Chargers at Bills (+1)
Bills at Minnesota Vikings (-10)
Bills at Green Bay Packers (-9.5)
Tennessee Titans at Bills (Pick 'em)
Bills at Houston Texans (-6)
Bills at Indianapolis Colts (-2)
New England Patriots at Bills (+4.5)
Chicago Bears at Bills (-1.5)
Bills at New York Jets (-1)
Jacksonville Jaguars at Bills (+4.5)
Bills at Miami Dolphins (-1)
New York Jets at Bills (-4)
Detroit Lions at Bills (Pick 'em)
Buffalo Bills at New England Patriots (-10.5)