Francesca's has closed its store at Boulevard Mall.
The women's clothing and accessories retailer decided not to renew its lease when it expired at the end of March.
There are three remaining Francesca's locations in the Buffalo Niagara market; at the Walden Galleria, Fashion Outlets of Niagara Falls and at the Orchard in Orchard Park.
Boulevard Mall has lost more than $100 million in appraised value over the past 10 years. Its former owner, Forest City Realty Trust, defaulted on a loan last year that the mall served as collateral for. In December, Forest City walked away, handing over ownership to its lender, LNR Partners.