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DOWNING - David M. April 8, 2018, beloved husband of 24 years to Karen S. (nee Sweeney) Downing; devoted father of Joseph, Stephen, David, Jr. and Ethan Downing; dearest son of the late Franklin G. and Dolores "Punkin" (nee Connelly) Downing; dear brother of Stephen W. Downing, MD, Franklin G. (Shari) Downing, Jr., Matthew M. (Donna), Molly D. (W. James) Regan and Gretchen M. (Rodrick) Cappiello; also survived by many loving nieces and nephews. Family and friends are invited to assemble Friday, April 13th at 10:30 AM at St. Michael Church, 651 Washington Avenue, Buffalo to celebrate a Mass of Christian Burial. In lieu of flowers, memorial contributions can be directed to Cholangiocarcinoma Immunotherapy Research. Checks should be made out to University of Pittsburgh and sent to: UPMC Hillman Cancer Center Pavilion, Suite 1B, 5150 Centre Avenue, Pittsburgh, PA 15232. Share your condolences online at

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