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Mark Gaughan's Matchup Watch: Which Bortles shows up?

Matchup Watch: Bills at Jaguars

Bortles vs. Bills' safeties

The Bills need to goad the Jaguars' quarterback into some mistakes. He threw 13 interceptions this season, ranking 19th in INT percentage. He threw five picks in the last two games. Under pressure last week against the Titans, he was 1 of 11 with two picks, according to Pro Football Focus. The Bills disguise coverages well, and Bortles doesn't have the quickest release or the best pocket presence. However, the Jags make things simpler for him with half-field reads. If Bortles has a clean pocket, he can sling it. He passed for 300-plus yards in three of his last five games, and he has nine 300-yard games the past two years. (Tyrod Taylor has one.)

Campbell vs. Mills

All of the Bills' offensive linemen have tough matchups. This may be the toughest, and Mills has battled a sore ankle this week. Seantrel Henderson is his backup. Campbell is a rare physical specimen – 6-foot-8 and 282 pounds and with a huge wingspan. He tied for second in the NFL in sacks this season (14.5) and made his third Pro Bowl. Even though he's exceptionally tall, he gets pretty low and plays with good leverage against the run. He also plays with discipline. The Bills might be able to get around his end on some read-option runs. Taylor will have to maneuver around him.

Jags OL vs. Bills' DL

The Bills have had some rough moments against physical running teams like the Saints and Jets this season. True, the Saints gave everyone problems. But Jacksonville has a three-headed running back committee that has the ability to wear down the Bills' front seven. Will the Jags try to power up? Jacksonville used "heavy" run formations on 25 percent of first-down plays this season. The good news for the Bills is Jacksonville hasn't dominated on the ground of late. The Jags like to run behind quality right tackle Jeremy Parnell. Can Eddie Yarbrough and Ryan Davis set the edge vs. him? That's not a great matchup for Buffalo. But the left side of the Jags line (tackle Cam Robinson and guard Patrick Omameh) is iffy. The Bills need to win that battle. Kyle Williams needs to dominate Omameh and right guard A.J. Cann.

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