The Bills are heading to the playoffs and get a meeting with former coach Doug Marrone and the Jacksonville Jaguars.
The Bills are the No. 6 seed in the AFC and the Jaguars are the No. 3 seed.
Game time is 1 p.m. on Sunday in Jacksonville. The game will air on CBS.
Bookmaker.eu opened the Bills as a 7.5-point underdogs against the Jaguars
Tennessee and Kansas City will be played Saturday at 4:30 in the other AFC game on ESPN.
In the NFC, Atlanta will play at the Los Angeles Rams on Saturday at 8:15 (NBC). Carolina faces New Orleans at 4:40 on Sunday on Fox.
Here is the full rundown:
Tennessee at Kansas City, 4:30, ESPN
Atlanta at Los Angeles Rams, 8:15, NBC
Buffalo at Jacksonville, 1, CBS
Carolina at New Orleans, 4:40, Fox