As the Bills begin preparations for Sunday's game against the Miami Dolphins, wide receiver Kelvin Benjamin (knee), defensive tackle Kyle Williams (groin), cornerback Shareece Wright (concussion protocol) and offensive lineman Ryan Groy did not practice Wednesday.
Groy is sick and has not suffered an injury.
Cornerback E.J. Gaines (knee) was limited. Gaines did not play Sunday against the New England Patriots.
Tight end Charles Clay (knee) also was limited as has been the case for much of the last few weeks.
The Bills continued a flurry of transactions in the last 24 hours, adding offensive tackle Josh James on the practice squad Wednesday morning. On Tuesday, the Bills released defensive tackle Deandre Coleman and placed running back Travaris Cadet and wide receiver Andre Holmes on injured reserve.
Running back Marcus Murphy, wide receiver Malachi Dupre and defensive tackle Ricky Hatley were added to the 53-man roster. Defensive tackle Marquavius Lewis and linebacker Xavier Woodson-Luster were signed to the practice squad.