Bills vs. Colts: 68 games all-time.
Bills record: 36-31-1 (.537).
First game: On Nov. 15, 1970, Buffalo and the then Baltimore Colts played to a 17-17 tie. The Bills, just 3-5 coming into this game, took an early 14-0 lead against the 7-1 Colts, but Baltimore found their stride and went on a 17-3 run.
Longest Bills winning streak: Six games, from Nov. 12, 1989, to Sept. 20, 1992.
Longest Bills losing streak: Six games, from Oct. 1, 2000, to Nov. 12, 2006.
Most points for: 42 points, in a 42-6 victory on Oct. 13, 1991.
Most points against: 58 points, in a 58-20 loss on Dec. 12, 1976.
Biggest win: 38 points, in a 38-0 victory on Sept. 20, 1992.
Biggest loss: 43 points, in a 43-0 loss on Oct. 10, 1971.
All-time Bills leaders against the Colts
Passing leaders: Hall of Famer Jim Kelly leads with 300 pass completions and 3,752 passing yards. Joe Ferguson bested Kelly in touchdown passes — 31 to 28 — but played two more games. And Canadian Football Hall of Famer Doug Flutie stands atop with a 64.55 completion percentage and a 97.7 passer rating among quarterbacks with at least two starts — he had four.
Rushing leaders: Thurman Thomas tallied 1,230 yards on the ground against the Colts, but he did so in 22 games; O.J. Simpson had just 1,197 rushing yards in nine fewer games against the Colts. Antowain Smith had eight touchdown rushes, and Kenneth Davis takes the rushing average at 5.44 yards-per-touch among backs with at least 50 carries.
Receiving leaders: Andre Reed had an incredible 128 receptions for 1,718 yards and 16 touchdown catches against Indianapolis, the most not only by any Bills player, but also the most by any player on any team in history against the Colts. Quinn Early averaged 20.67 yards on 18 catches and Frank Lewis averaged 20.64 yards on 33 catches, your leaders in yards-per-catch, dependent upon what you'd consider a reasonable minimum number of catches.
Special teams leaders: Steve Christie leads by far and away with 34 field goals on 43 attempts. Scott Norwood was a perfect 41-for-41 on extra-point attempts. Both Nate Clements and John Jimbrough have punt return touchdowns, and on Sept. 24, 1978, Curtis Brown brought a kick back 102 yards for a touchdown.
Defensive leaders: Hall of Famer Bruce Smith had 25.0 sacks against the Colts, accounting for 12.5 percent of his all-time sacks lead of 200.0. Charles Romes' five picks are good for the lead and Henry Jones tops with a pair of pick-sixes.
Bills single-game records against the Colts
Passing leaders: Joe Ferguson threw four touchdown passes in a 35-3 win on Sept. 13, 1981, his 317 passing yards on Sept. 30, 1979, are also good for a head-to-head best. But on Dec. 15, 1991, Jim Kelly completed 81.82 percent of his passes with a near perfect passer rating on 151.3.
Rushing leaders: Fred Jackson had 212 yards on the ground in a 30-7 win on Jan. 1, 2010. On Sept. 21, 1997, Antowain Smith had 12 rushing attempts for 129 yards, 10.75 yards-per-touch, with three touchdowns, emphasized by his third touchdown, a 54-yard rushing score to give Buffalo a 30-29, the Bills held on to win 37-35.
Receiving leaders: Eric Moulds is the receptions leader, with ten, in a 31-14 loss on Sept. 12, 1999, while the single-games receiving yards lead belongs to Frank Lewis, who tallied 158 yards in a 14-13 loss on Oct. 21, 1979. Chris Burkett caught five passes for 145 yards in a 24-14 loss on Dec. 14, 1986. Five times ever has a Bills' receive had a pair of receiving touchdowns, four belong to Andre Reed, the other, by Bob Chandler in a 42-35 loss on Nov. 9, 1975.
Defense/special teams leaders: Bruce Smith tallied 4.0 sack on Dec. 9, 1990, in the Bills 31-7 victory over the Colts. Cary Harris, Doug Jones, Henry Jones and Mark Kelso each had games with two picks; Henry Jones took both of his to the house fro six in a 38-0 romping on Sept. 20, 1992. Scott Norwood had four field goals in a 26-10 win on Sept. 9, 1990.
Sunday’s game: Line is currently dead on this game; follow me on Twitter (@theaceofspaeder) for my pick when it drops.
Many of the stats in this article made possible by the Pro Football Reference Play Index.