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Mark Gaughan's Matchup Watch: Colts dinged at LB

LeSean McCoy vs. Colts LBs

The Colts' defensive line has played well. But the linebacking corps took a big hit this week with the loss of John Simon for the season to a neck injury. Former Browns top pick Barkevious Mingo takes his left outside spot, and he has been productive rushing the passer. But he's not as good against the run. Second-year inside starter Antonio Morrison has been a big liability against the run. Maybe the Bills can take advantage of those two in both the run game and the short pass game to McCoy.

Kyle Williams vs. Jeremy Vujnovich

Vujnovich was undrafted out of Division III Louisiana College in 2013 and appeared in only two games before this season. He has started every game for the Colts but has struggled, along with the rest of the Colts' front offensive five. Vujnovich was one of just seven D-III players who made NFL rosters to open the season. (The most prominent remained San Francisco receiver and former Colt Pierre Garcon.) Williams has the giant experience edge (158 starts to 12). If the Bills can get the Colts' line moving laterally, it could yield pressure on quarterback Jacoby Brissett.

Frank Gore vs. Bills' LBs

The Colts' 34-year-old running back ranks fifth on the NFL's all-time rushing list with 13,697 yards. He just passed No. 6 LaDainian Tomlinson and No. 7 Jerome Bettis. No. 4 Curtis Martin is 405 yards ahead of him. Gore stands 16th in the NFL this season with 632 yards and a 3.6-yard average. He's a between-the-tackles runner who's good at making himself "small" through the hole. If the Bills shut him down, they could add to the Colts' NFL-leading sacks-allowed total of 51.

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