LeSean McCoy was held out of practice Friday with what coach Sean McDermott described as "a little bit of knee soreness."
However, the Buffalo Bills' running back is expected to play Sunday against the New England Patriots, McDermott said.
"Does not look like he will miss it at this point; looks good that he’ll play," the coach said.
McCoy was not listed as questionable, the only other injury designation besides out.
His knee issue first surfaced Thursday, although he was a full participant in practice then.
Not surprisingly, wide receiver Kelvin Benjamin was ruled out of Sunday's game. He has not played or practiced since suffering the injury against the Los Angeles Chargers on Nov. 19.
Left tackle Cordy Glenn will again be sidelined with foot and ankle problems.
Running back Mike Tolbert (hamstring) and guard John Miller (ankle) are also for the Patriots game.
Tight ends Charles Clay (knee) and Nick O'Leary (back), tackles Seantrel Henderson (illness) and Conor McDermott (chest), wide receiver Jordan Matthews (knee), defensive end Eddie Yarbrough (chest), and fullback Patrick DiMarco (ankle) are questionable.
Henderson missed practice, along with McCoy, Benjamin, Glenn, Tolbert and Miller.
Clay, O'Leary, Matthews, DiMarco, Yarbrough and McDermott practiced on a limited basis.
The Patriots list wide receiver and former Bill Chris Hogan (shoulder) and offensive tackle Marcus Cannon (ankle) as out for Sunday.
Linebackers Marquis Flowers (knee), Kyle Van Noy (calf) and Trevor Reilly (concussion); defensive lineman Trey Flowers (rib), center David Andrews (illness), tackle LaAdrian Waddle (ankle), and cornerback Eric Rowe (groin) are listed as questionable.
McDermott received a great deal of praise for the defensive strategy that he and coordinator Leslie Frazier used to stifle Chiefs quarterback Alex Smith in last Sunday's 16-10 victory at Kansas City.
Asked about having the same success against Tom Brady, McDermott said, "There’s probably not a scheme out there that’s been invented to this date that he hasn’t seen. It’s a challenge for a lot of reasons, to play this (Patriots) football team, one of which is (that)."