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A win on Sunday will give Tom Brady most wins ever recorded against a single opponent

We know that Patriots QB Tom Brady owns the Bills. He has more wins, more touchdowns passes and more 300-yard games against the Bills than any other team, and no opponent has more of those against the Bills. This weekend he can become the winningest quarterback of his era in games played at the Bills' stadium.

But a win Sunday would also mean Brady has dominated the Bills like no player has ever dominated an opponent before.

Brady is 26-3 all-time against the Bills. That's tied with Brett Favre for the most wins any player has ever recorded against a single opponent. Favre had 26 wins against the Lions with the Packers and Vikings.

Brady's 24 wins against the Jets ranks third on the list of all-time quarterback wins against a single opponent, while Favre's 23 wins against the Bears is fourth. Dan Marino (22 vs. Colts) and Ben Roethlisberger (22 vs. Browns) are tied for fifth. George Blanda – the longtime Bears, Oilers and Raiders quarterback/kicker – beat the Broncos 25 times in his career, though not all of those came as a quarterback. (Jim Kelly's high mark, if you're curious, was 15 against the Jets, although he played six fewer seasons than Marino.)

These players have the most wins against the Bills while playing any position, according to Pro Football Reference:

26 – Tom Brady, Patriots QB, 2001-present
24 – Bob Kuechenberg, Dolphins OL, 1970-83
22 – Nat Moore, Dolphins WR, 1974-86
21 – Ed Newman, Dolphins OL, 1973-84
Multiple players tied at 20.

The quarterback with the second-most wins against the Bills is Bob Griese (18), who was the Dolphins' primary quarterback during their NFL-record 20-game winning streak against the Bills, which spanned the entire 1970s.

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