The Raiders were without Marshawn Lynch on Sunday after his one-game suspension for putting his hands on an official.
That meant bigger roles for Jalen Richard and DeAndre Washington.
Richard had five carries for 21 yards and five receptions for 35 yards. Washington posted six carries for 26 yards and caught eight passes for 62 yards and a touchdown. But they each lost a fumble.
Richard was not at all impressed with his performance, using the term "poo butt" on Twitter.
I was poo butt today ...
— Jalen Richard (@RocketRich30) October 29, 2017
Quarterback Derek Carr took a more diplomatic stance.
"Any time you don’t have a teammate, you miss them, especially a starter," he said. "Any time you don’t have a starter at any spot it hurts, because you want your brother there. You want to play with them. Obviously, we have a lot of faith in those guys. They had a couple mistakes that they wish they hadn’t made, and that’s going to happen in games.
"The thing that I like to see is that they kept playing. Sometimes it sucks out there. Sometimes it’s going to be hard and sometimes it’s going to be a little bit embarrassing, but they kept their eyes good in protection. They kept their check-down rules very well, they did a great job there. They did a great job after the catch. Again, they (the Bills) played really soft, and they (Jalen Richard and DeAndre Washington) have pretty much got to be heroes. They’ve got to go get us what they can. I thought they did a really good job with that. We have all the faith in the world with those guys, but any time you miss a starter, you obviously miss the guy."