Khalil Mack vs. Jordan Mills
It will not just be the Bills' right tackle against the Raiders' superstar edge rusher. The Bills often will have a running back or a tight end on Mack's side of the field. Mack rushes off right tackle 75 percent of the time and off left tackle 25 percent. One of the few times Mack was one-on-one with Mills in last season's game, Mack hit Tyrod Taylor and forced an interception. He also had a sack and forced fumble on Taylor after beating a double-team of Mills and Mike Gillislee. Mack has 4.5 sacks, six QB hits and 20 hurries this season, according to Pro Football Focus.
Bills DTs vs. Raiders middle three
The Raiders have the best guard-center-guard trio in the NFL in left guard Kelechi Osemele, center Rodney Hudson and right guard Gabe Jackson. It's hard to out-muscle them. The Bills need to get occasional pocket push because the Oakland wideouts are so good. Rex Ryan's plan last year was to rush three and drop eight into coverage. It didn't work. Quick pressure up the middle in a four-man rush may not lead to a sack of Derek Carr but it can throw off the timing of the Raiders' three-step passing game. Kyle Williams needs to be good vs. Jackson. Marcell Dareus has a tough matchup against Osemele and Hudson. Dareus played 41 snaps last week. This would be a good game to show NFL scouts (for next season) that he can be elite against elite competition.
Tyrod Taylor vs. Raiders' back seven
Oakland stands 23rd in the NFL in passing yards allowed and 32nd (last) in interceptions with none. The Bills must find a way to exploit the Oakland linebackers and cornerbacks. Oakland's best corner, David Amerson, is nursing a foot injury. His status is uncertain. T.J. Carrie has been pretty good in the slot. But veteran Sean Smith has been scorched this season. Tight ends have had success against the linebackers. Veteran Navorro Bowman will be playing his second game for the Raiders at one inside linebacker spot. All three guys who have seen time at the other inside spot (Cory James, Nicholas Morrow and Marquel Lee) are on the injury report. A 250-plus yard day from Taylor is a must.