Richie Incognito vs. Gerald McCoy
The Bills' star guard has two tough assignments in a row after going up on occasion two weeks ago against Cincinnati defensive tackle Geno Atkins. Now Incognito faces a player who's arguably a tad better than Atkins. The top four 3-technique defensive tackles in the league, in one order or another, are the Rams' Aaron Donald, the Bucs' McCoy, the Eagles' Fletcher Cox and Atkins. McCoy, the third overall pick in 2010, has made five straight Pro Bowls and is a three-time, first-team All-Pro. He has a very fast get-off. Watch for him exploding off the snap. McCoy has 35.5 sacks since 2013, tops among NFL defensive tackles.
Bucs LBs vs. Bills run game
Just like two weeks ago in Cincinnati, the Bills are facing a good linebacking corps, arguably among the top 10 in the league. They play downhill, aggressively attacking running gaps. Weak-side linebacker Lavonte David was a Pro Bowler in 2015. Middle backer Kwon Alexander, out the past four games with a hamstring injury, is healthy and was the Bucs' leading tackler last year. Rookie strong-side guy Kendell Beckwith is off to a good start. The Bills should try to test his coverage ability. The Bucs will keep all three backers on the field at times on third down. Having some success early in the play-action pass game would help keep the Bucs' trio a bit more honest against the run.
Mike Evans vs. Bills CBs
The Bucs' star is one of the top "open-when-he's-not-open" receivers in the NFL. This isn't to say he doesn't get open. He has deceptive speed and can get behind the defense. But he is great at making contested catches. He has long arms, strong hands and he's good at high-pointing the ball in the air. Evans was targeted 10.8 times a game last year, tops in the NFL. He had 96 catches for 1,321 yards last season, fourth in the league. He's on pace for 86 catches this year. The Bucs will move him around, so all of the Bills' cornerbacks likely will see him at some point in the game.