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Pregame primer: Everything you need to know for Bills-Broncos, plus five things to watch for

Hydrate, Bills fans.

In what is expected to be one of the hottest home games ever, the Buffalo Bills will look to cool down the red-hot Denver Broncos Sunday at New Era Field. Denver comes into the game off a dominating Week Two victory over Dallas, while the Bills missed a chance to steal a road victory in Carolina.

Here are all the details you need for Sunday's game, plus five things we'll be watching for:

• TV: Ch. 4. Announcers: Spero Dedes (play by play), Adam Archuleta (color analyst).

• Radio: Bills Radio Network. Buffalo-WGR 550 AM; Toronto-Fan 590 AM; Rochester-WCMF 96.5 FM and WROC 950 AM; Syracuse-WTKW 99.5 FM and WTKV 105.5 FM. Announcers: John Murphy (play by play), Mark Kelso (color analyst).

• Series history: Bills lead, 19-16-1. The Bills are looking to start 2-0 in the AFC for the first time since 2011.

• Uni watch: The Bills are going with blue jerseys paired with white pants against the Broncos.

• Did you know? Bills offensive coordinator Rick Dennison played linebacker for the Broncos from 1982-90. He was also Denver's offensive coordinator the past two seasons, helping the team win Super Bowl 50.

• Next up: The Bills visit the defending NFC champions when they take a trip to Atlanta in Week Four.

Here are five things to watch for against the Broncos:

1. How does Jordan Mills handle Von Miller? The biggest mismatch on paper is the Bills' right tackle lining up against the Broncos' All-World defensive end. Miller is simply too good to be blocked one on one. That means the Bills will have to put a tight end or perhaps a running back on his side on obvious passing downs to give Mills some help.

2. Who replaces Marcell Dareus? When the defensive tackle went out of the lineup against Carolina last week, Adolphus Washington and Cedric Thornton split the reps equally. Dareus did not practice all week, so the Bills should at least have a plan for how his reps will be split up. The weather will also be a factor here as coach Sean McDermott tries to keep Kyle Williams fresh. That could mean recently signed Deandre Coleman gets meaningful playing time as well.

3. Can Shady get back on track? The No. 1 takeaway from the loss to Carolina is that the Bills' offense is going to struggle badly if running back LeSean McCoy isn't able to get going. That was the case against the Panthers, who held McCoy to just 9 rushing yards on 12 carries. Denver's run defense has been dynamite through two weeks, most recently holding Dallas' Ezekiel Elliott to 8 yards rushing. Dennison knows the Broncos' personnel well, and will need to come up with a game plan that gets McCoy better involved than he was a week ago.

4. Can any of the receivers get open? Another bad matchup on paper for the Bills is their wide receivers against Denver's top cornerback pairing of Aqib Talib and Chris Harris Jr. If Denver takes the predictable approach of loading the box to stop McCoy, the Bills will need Jordan Matthews, Zay Jones and Andre Holmes to show they can beat one-on-one coverage and get open. That will force the Broncos to respect the Bills' passing game. Against Talib and Harris, however, that's much easier said than done.

5. What will happen during the national anthem? Recent comments from President Donald Trump about what should happen to players who sit or kneel during the national anthem have led many to believe there will be widespread protests throughout the NFL. The Bills have not had a player protest in any way the first two weeks of the regular season, but that could change Sunday.

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