Marcell Dareus' ankle injury will keep him out of Sunday's game against the Broncos. Ditto for left tackle Cordy Glenn.
The Bills will be without their two highest-paid players Sunday, missing one key lineman on each side of the ball.
Dion Dawkins is slated to make his first career start in place of Glenn. The second-round pick has played 44 percent of offensive snaps this season while rotating when Glenn, who has been dealing with foot and ankle problems since last year.
As for Dareus, another absence only reinforces the idea that the Bills paid him way too much money. He has been able to play only a shade over half of their games the last two seasons.
With Marcell Dareus out this week, he will have missed nine of the #Bills last 19 games.
— Nick Veronica (@NickVeronica) September 22, 2017
Cedric Thornton, come on down: With Darues out, that could mean a bigger role for DT Cedric Thornton. Get to know him in this profile from Vic Carucci. The man has seen some stuff.
Sign me up: If you think Pilates is for women, you might not want to say that around Lorenzo Alexander. The Bills' chiseled linebacker credits it with extending his career.
Mailbag: Are these college quarterback prospects really worth it?
Matchups to watch: Will Jordan Mills be able to handle Von Miller?
X's and O's: With the Brocnos banged up on the offensive line and the Bills' DBs likely to play off of Denver's talented receivers, Mark Gaughan breaks down a quick-strike play quarterback Trevor Siemian could use against the Bills.
Start 'em, sit 'em: Our local fantasy expert says Jay Cutler is a decent streaming option this week. As for fantasy players in the Bills-Broncos game, there's not a lot to be excited about, but the Broncos' top receivers usually get their numbers.
Ugh. You knew Sammy Watkins was going to have a big game at some point, right? And Robert Woods. And Marquise Goodwin. And Nickell Robey-Coleman and all of the other ex-Bills. But did it all have to happen in the same game?
Brace yourself, Vic Carucci wrote – more of that is on the way.
Sean McDermott acknowledged it was "hard to watch" for Bills fans, but said he was happy for Watkins and the others.
Why doesn't Tyrod Taylor audible more? I have wondered this. Jerry Sullivan asked him.
Corey Graham's ironman streak will end: Buffalo native Corey Graham will miss a game Sunday for the first time since 2007.
Have you seen those big medical tents on the sideline this year? The Bills were one of the teams that pushed for that.
How Jordan Poyer got to Buffalo: The unlikely star of the Bills' defense so far is safety Jordan Poyer. Get to know him in this Jay Skurski piece.
Are the Broncos 'ripe for an upset'? That's what a Denver Post columnist wrote this week.
Power rankings: Vic Carucci ranks every team from 1-32.
Podcast: Spotrac's Mike Ginnitti discusses the Bills' salary cap situation.