The Bills put the game away in just 23 seconds of game time early in the fourth quarter.
With 10:59 left, LeSean McCoy took a handoff and went virtually untouched into the end zone from 19 yards out, putting the Bills ahead, 31-16. Left guard Richie Incognito pulled on the play and sprung McCoy with a key block, which is why McCoy let Incogntio spike the ball in the end zone.
SHADY! SHADY! SHADY!
— NFL (@NFL) October 16, 2016
On the ensuing kickoff, Nickell Robey-Coleman laid the lumber on 49ers returner Keshawn Martin, who fumbled. Jonathan Meeks came out of the pile with the ball at the 27-yard line.
McCoy was interfered with on a pass into the end zone on the Bills’ first play, which gave them the ball on the 5. Taylor hit Robert Woods on next play, putting the Bills up 38-16 with 10:36 remaining.
No doubt: Rex Ryan took Tyrod Taylor out of the game on the next drive and let EJ Manuel take over with 9:05 remaining. His first drive went for a touchdown on a 44-yard run from Mike Gillislee went 44 yards.
Career day: McCoy's third touchdown gave him his third career three-score game. The others came with the Eagles, on Sept. 19, 2010 and Dec. 18, 2011.
Sack leader: Lorenzo Alexander had one sack in the fourth quarter, which moved him back ahead of Denver's Von Miller for the league lead (8).