Sammy Watkins was 10 yards away from his career-high and had only his second two-touchdown game.
It was halftime. The Buffalo Bills led the Kansas City Chiefs, 16-14.
Watkins didn't catch another pass the rest of the game. The Bills lost, 30-22.
The loss is a wham-bam jolt to the Bills wild-card playoff chances. The entered Sunday's game at Arrowhead Stadium tied with the Chiefs at 5-5. Now the Chiefs are a game ahead and hold the head-to-head tiebreaker.
"It means we're out of mulligans," Bills coach Rex Ryan said.
Ryan bungled several chances to challenge calls that could've saved the Bills.
The ball appeared to drag on the ground on Jeremy Maclin's 37-yard catch that set up the Chiefs' first touchdown, but the Bills didn't challenge.
With the game on the line in the closing minutes and down a touchdown, officials ruled Bills receiver Chris Hogan didn't hang onto a pass. Replays indicated he did, but the Bills didn't challenge that call either.
Instead, the Bills failed on the two challenges they did make. Once was an incomplete pass Robert Woods clearly dropped. The other was the spot of the ball on a Tyrod Taylor scramble.
Taylor set a career mark with 291 passing yards and three touchdowns. He ran for 46 yards.
Buffalo's run defense was dominated by an injury-riddled offense. With three starting offensive linemen sidelined for much of the game, reserve running back Spencer Ware ran 19 times for 114 yards and a touchdown. He had four double-digit runs with a long of 35 yards.
Buffalo was without defensive linemen Kyle Williams and Mario Williams and lost backup Alex Carrington to a knee injury at the end of the third quarter.