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Fourth-quarter analysis: Bills make life difficult for Andrew Luck

The Buffalo Bills' defense made the Indianapolis Colts work for every inch Sunday.

It resulted in a 27-14 victory in the season opener at Ralph Wilson Stadium.

Safety Aaron Williams intercepted Colts quarterback Andrew Luck at the two-minute warning in the fourth quarter, officially ending any hopes of an Indianapolis comeback. Williams' interception, which came after cornerback Mario Butler tipped the ball away from Colts receiver Andre Johnson, was the second of the day thrown by Luck. He finished 26 of 49 for 240 yards, averaging just 5.0 yards per attempt and compiling a quarterback rating of 63.6.

Coming through: Bills kicker Dan Carpenter, on Rex Ryan's hot seat after a bad preseason, was perfect Sunday, going 2 for 2 on field goals and 3 for 3 on extra points. Carpenter's 45-field goal in the fourth quarter re-established a three-possession lead by putting the Bills up, 27-8.

Costly turnover: Both teams had taken good care of the ball until Colts rookie receiver Phillip Dorsett botched fielding a punt. His fumble was recovered by Bills linebacker Randell Johnson. The turnover, which led to Carpenter's field goal, came after the Bills were held to a three-and-out and prevented Colts quarterback Andrew Luck from getting the ball back down just two possessions.

The rest of the quarter-by-quarter analysis: 

First-quarter analysis: The Tyrod Taylor Era starts ... eventually

Second-quarter analysis: Karlos Williams' first career carry is one to remember

Third-quarter analysis: Bills, Colts go on sustained drives

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