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First-quarter analysis: The Tyrod Taylor Era starts ... eventually

Let the record show that Matt Cassel will go down in history as the Buffalo Bills' starting quarterback in the 2015 season opener against the Indianapolis Colts at Ralph Wilson Stadium.

For one play, that is.

Cassel took a shotgun snap on the Bills' first play, with expected starter Tyrod Taylor lined up as a slot receiver in the slot on the left. Taylor came around behind Cassel for a fake handoff, with the ball going to running back LeSean McCoy for a loss of 6 yards.

It was back to normal after that, though, with Taylor taking over at quarterback. His first two full drives of the first quarter ended in punts as the game was scoreless after 15 minutes.

Injuries at safety: The Bills were down to third-string safety Duke Williams at one point during the first quarter after starter Corey Graham was hurt on the game's first play and backup Bacarri Rambo went down on the first play of the Colts' second possession. Graham, who went to the locker room for evaluation of a possible concussion, was ruled out, while Rambo was able to return to the field.

First challenge: Bills coach Rex Ryan won his first challenge of the season, successfully throwing the flag on what was ruled to be a 13-yard completion by Colts receiver Donte Moncrief along the left sideline. Moncrief's foot, however, was out of bounds, making it incomplete.

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