MASON, Ohio -- A weary Rafael Nadal and an off-target Roger Federer got knocked out of the quarterfinals of the Western & Southern Open on Friday. No. 1 Novak Djokovic had to scuffle to avoid an upset, too.
Playing a day after he spent five hours on the court, Nadal faded in a 6-3, 6-4 loss to American Mardy Fish, who had never beaten the second-ranked Spaniard.
Later, the third-seeded Federer struggled with his groundstrokes during a 6-2, 7-6 (3) loss to a sore-shouldered Tomas Berdych, who has won three of their last four matchups. Djokovic survived a match of long rallies and electrifying shots, beating Gael Monfils, 3-6, 6-4, 6-3.
In the wide-open women's bracket, second-seeded Vera Zvonareva, No. 4 Maria Sharapova and No. 9 Andrea Petkovic advanced in straight sets. Jelena Jankovic moved into the semifinals when Peng Shuai withdrew with a sore left hip.
The men's bracket finally got its first big upsets.
A worn-out Nadal simply couldn't keep up. Fish reached the tournament's semifinals for the second straight year -- he lost to Federer in the championship match in 2010.
"It was a great opportunity for me, catching him in a place where he maybe was not as confident as in his previous matches or tournaments," said Fish, who counted it among his top five career wins.
Nadal's tired legs and burned fingertips had something to do with it.
A day earlier, the 25-year-old Spaniard needed three tiebreakers and 3 hours, 38 minutes to beat Fernando Verdasco. That was followed by a 70-minute doubles match. He ended the day with blisters on his left foot.
Plus, his right hand was bothering him -- he burned the tips of his index and middle fingers on a hot plate at a restaurant before the tournament began and had to play with them heavily bandaged.
"I didn't play well here, especially," Nadal said. "A little bit unlucky week for me with the burned fingers and the very long match yesterday."
Fish knew everything was on his side this time in the lopsided rivalry -- he'd never come close to beating Nadal in their six previous matches, winning a total of two sets.
"I really felt I could win, maybe should win in that scenario," Fish said.
Fish, the highest-ranked American on the tour at No. 7, will play fourth-seeded Andy Murray, who advanced with a 6-3, 6-3 win over 10th-seeded Gilles Simon of France.
Federer had trouble with his groundstrokes and never had a chance to break Berdych's serve. The Swiss star had an uncharacteristic 29 unforced errors and hit three forehands wide during the tiebreaker.
"I definitely didn't feel I was getting a great read on his first serve today," Federer said. "He served well and played a good match. Unfortunately, I didn't play a very good tiebreaker today."
Twice during the second set, Berdych got the side of his right shoulder rubbed by a trainer. He kept going and closed it out, then dropped out of his doubles match.