Late substitute Brent Lillibridge made two spectacular catches in a row to save the White Sox in the ninth inning, and Gavin Floyd pitched Chicago to a 3-2 victory Tuesday night over the suddenly slumping New York Yankees.
Lillibridge entered as a pinch-runner in the eighth and scored on Paul Konerko's go-ahead homer off struggling setup man Rafael Soriano (1-1).
Lillibridge stayed in the game in right field and, with two on in the ninth, raced back to the wall to make a terrific catch of Alex Rodriguez's opposite-field drive for the second out, robbing the slugger of a game-tying hit and keeping the runners at first and second.
Robinson Cano then hit a line drive to right and Lillibridge charged in, making an all-out dive to snag the ball for the final out.
Floyd took a three-hitter into the ninth but was pulled after Derek Jeter led off with an infield single. Curtis Granderson sacrificed against Matt Thornton, and Mark Teixeira worked a walk.
White Sox manager Ozzie Guillen, still looking for a reliable closer in his shaky bullpen, called on Sergio Santos for the second consecutive night. He got two outs -- thanks to Lillibridge -- for his second straight save and Chicago's third in nine chances this season.
The last visiting pitcher to win at the old Yankee Stadium in 2008, Floyd (3-1) struck out a season-high 10 to win his second straight start.
Cano and Brett Gardner homered for the Yankees, held to three singles by journeyman Phil Humber and two relievers during a 2-0 loss in the series opener Monday night. This time, they wasted a strong start by rookie Ivan Nova, who left with a 2-1 lead after a career-high 6 1/3 innings.
New York, now 18-5 following shutout losses since the start of the 2008 season, has lost two in a row for the first time this year.
David Robertson preserved New York's narrow lead in the seventh, but Soriano hit Carlos Quentin with a one-out pitch in the eighth and Konerko sent his 371st career home run rocketing to left.
After saving an AL-best 45 games for Tampa Bay last year, Soriano signed a $35 million, three-year contract with the Yankees in January to be the bullpen bridge -- and possible successor -- to star closer Mariano Rivera.
But the right-hander has a 7.84 ERA in 11 appearances and was booed Tuesday night by the crowd of 40,785. He has given up nine earned runs in 10 1/3 innings after yielding only 12 all last season.
New York had three chances to retire Alex Rios in the fifth and never did it.
Granderson was unable to make a shoestring catch on Rios' line-drive single to center. Rios then stole second, catching a break when Cano dropped a strong throw that could have been in time. Finally, Rios slid home ahead of the throw from right fielder Nick Swisher on Gordon Beckham's RBI single.