"Hello, this is Talk All Night with Lenny. What's up?"
"Hi, Lenny. This is Marlene. I've been a listener since you first came on the air. You're the best!"
"Thanks. What can I do for you?"
"Well, for one thing, (1) in regard to your last caller, everything you said was right! However, (2) with regard to Sam, I think you let him off too easily. I'd have been more severe with the jerk! Now, (3) regarding Archie, who does he think he is? But (4) in relation to Dan, he definitely hit the nail on the head. Finally, (5) in terms of guests, you have the best and "
"Thank you," said Lenny. "Let's say hello to Hy."
Let's not. Let's look at what could be disposed of in what Marlene said:
(1) get rid of "in regard to" and say "Everything you said to your last caller was right!"
(2) lose "with regard to" in favor of "However, I think you let Sam off too easily."
(3) "regarding" can be tossed, too, so you end up saying "Who does Archie think he is?"
(4) let go of "in relation to" and hang on to "Dan definitely hit the nail on the head."
(5) finally, ditch "in terms of" and say "you have the best guests."
Remember: You don't have to introduce what you're going to say with "in regard to," "with regard to," "regarding," "in relation to," "in terms of," unless you're padding a speech or a paper that's too short or you're moving on, as in, "Apples are fine for dessert. Regarding sweets, however, back off!" (Yes, you can also say "Apples are fine for dessert, but back off sweets!")