Peyton Manning, Colts, shredded Houston for 320 yards and five touchdowns, tying an NFL record with his third game this season with five TD passes. The Vikings' Daunte Culpepper set the record earlier this season.
Ben Roethlisberger, Steelers, became the first rookie QB to begin 7-0 since the NFL merger in 1970 with a 24-10 win at Cleveland.
David Garrard, Jaguars, had two TD passes in his second career start, including a game-winning 36-yarder to Jimmy Smith in overtime in a 23-17 victory over Detroit.
Daunte Culpepper, Vikings, completed 27 of 44 passes for 363 yards and four TDs. But Brett Favre, Packers, went 20 of 29 for 239 yards and four TDs as Green Bay won, 34-31.
Brandon Stokley, Colts, had five receptions for 132 yards, and teammate Dallas Clark caught three passes for 102 yards in a 49-14 rout of Houston.
The Saints' Joe Horn had five catches for 167 yards, including a decisive 42-yard TD reception, in a 27-20 victory against Kansas City.
Isaac Bruce, Rams, had seven catches for 104 yards, his fifth 100-yard game of the season.
The Falcons' Alge Crumpler had a career-best 118 yards, including a key 49-yard TD catch, as Atlanta defeated Tampa Bay 24-14.
The Panthers' Muhsin Muhammad caught three touchdown passes and had 123 yards receiving as Carolina beat San Francisco, 37-27.
Nate Burleson, Vikings, caught 11 passes for 141 yards and a score.
Emmitt Smith, Cardinals, ran for two TDs in a game for the first time in two seasons, leading Arizona past the Giants, 17-14.
Derrick Blaylock, Chiefs, subbing for injured Priest Holmes, ran for 186 yards and a touchdown at New Orleans.
Shaun Alexander, Seahawks, had 176 yards, going over 1,000 yards for the fourth straight season, but Seattle lost at St. Louis, 23-12. Marshall Faulk, Rams, had a season-best 139 yards on 18 carries.
Ahman Green, Packers, rushed for 145 yards on 21 carries in a 34-31 win over Minnesota.
Fred Taylor, Jaguars, had a season-high 144 yards rushing despite missing most of third quarter with leg cramps in a 23-17 OT win against Detroit.
Deuce McAllister, Saints, rushed for 127 yards and a touchdown on 16 carries against Kansas City.
Curtis Martin, Jets, scored twice in the first half and finished with 119 yards on 28 carries against Baltimore.
Tiki Barber, Giants, had 108 yards on 21 carries but only 28 yards in the second half in a 17-14 loss to Arizona.
Alex Brown sacked Billy Volek in the end zone, forcing a safety that gave the Bears 19-17 overtime win at Tennessee.
Ed Reed's interception in the end zone turned around the game for Baltimore against the Jets. Though his 104-yard return was wiped out by penalty, he stopped a drive that could have given New York commanding lead and instead set up a TD that pulled Baltimore within 14-7.
Robert Mathis, Colts, had three sacks and forced three fumbles against the Texans.
Titans cornerback Andre Dyson had two interceptions against Chicago.
Emmitt Smith, Cardinals, surpassed 18,000 yards rushing, the first player to do so.
Chicago's win over Tennessee marked the second time an NFL game ended in overtime on a safety. The first was Nov. 5, 1989, when Minnesota beat the Los Angeles Rams, 23-21, on a punt blocked out of the end zone.
The Colts improved to 82-81 in the RCA Dome, the first time since moving to Indianapolis in 1984 their home record has topped .500.
The Jaguars' Jimmy Smith had seven catches for 109 yards, passing James Lofton for 12th on the NFL career receptions list with 767 catches.
The Steelers remained the NFL's hottest team with their seventh consecutive win.
The Bears won their third straight for the first time since the end of the 2001 season.
Carolina snapped a six-game losing streak by winning at San Francisco.
Detroit's Joey Harrington had his streak of games with at least one TD pass snapped at eight in a 23-17 OT loss at Jacksonville.
Cleveland's Phil Dawson has made 27 straight field goals, the league's longest current streak.
Baltimore P Dave Zastudil was sidelined with a left shoulder injury, forcing backup QB Kordell Stewart to take over punting duties. Stewart averaged 35.4 yards.
Bears CB Alphonso Marshall sprained his left knee in the third quarter against Tennessee and did not return.
Tennessee OT Brad Hopkins will need surgery to repair several broken bones in his right hand.
Houston backup CB Jason Bell broke his right arm against Indianapolis.
Redskins DT Cornelius Griffin (hip) and LB Khary Campbell (knee) will have MRIs today.
"We just keep pumping them full of air and starches and fruits and stuff." -- Bengals coach Marvin Lewis on how his young defense performed so well in a 17-10 victory at Washington.
Compiled from News and wire service reports.