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Chiefs running back Priest Holmes against Bills middle linebacker London Fletcher

Holmes has terrific vision, exceptional quickness and change-of-direction skills, which allow him to anticipate blocks and make the appropriate cut once he gets through the line of scrimmage. For that reason, expect to see a heavy dose of counter and zone runs in this game to target Fletcher. Fletcher has been terrific against the run, but can't be overaggressive because Holmes is devastating as a receiver, especially on screen passes.

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