Peyton Manning, Colts, threw for 421 yards and four touchdowns, hitting 23 of 29 passes as Indianapolis beat Buffalo, 42-26.
Doug Flutie, Chargers, threw for 353 yards and two touchdowns, completing 23 of 38 passes in a 42-26 win at Dallas.
Kurt Warner, Rams, was 24 for 35 for 321 yards and three TDs in a 30-26 win over San Francisco.
Edgerrin James, Colts, had his fifth straight 100-yard effort, running for 111 yards and a touchdown on 23 attempts in beating Buffalo.
Marshall Faulk, Rams, Faulk rushed 18 times for 105 yards and caught eight passes for 79 yards in a victory at San Francisco.
Marvin Harrison, Colts, had seven catches for 146 yards and tied his career-high with three touchdown receptions. Teammate Jerome Pathon added 168 yards on nine receptions and one TD in a win over Buffalo.
The Bears' Marty Booker caught nine passes for 95 yards, and Marcus Robinson got seven for 99 in a 17-10 win over Minnesota.
James Thrash, Eagles, caught touchdown passes of 64 and 23 yards and had 10 receptions for 165 yards, both career highs, in a 27-3 victory at Seattle.
Isaac Bruce, Rams, had eight catches for 144 yards and a 39-yard TD as the Rams beat the 49ers for the fifth straight time.
Rookie defensive back Anthony Henry, Browns, had three interceptions vs. Detroit in a 24-14 win.
Takeo Spikes, Bengals, batted a pass to teammate Brian Simmons for a pivotal end zone interception in the first half, then returned one 66 yards in the fourth quarter to clinch a 21-10 victory over Baltimore.
Ryan McNeil, Chargers, had two interceptions in a victory at Dallas.
Vikings safety Robert Griffith broke his right leg on the opening kickoff at Chicago.
Jaguars running back Fred Taylor, who has a history of injuries, hurt his groin against Tennessee. The severity of the injury won't be known until at least today.
Garrison Hearst, who missed the last two seasons while recovering from a broken leg, suffered a concussion in the second quarter of the San Francisco 49ers' game against St. Louis.
Eagles halfback Duce Staley partially dislocated his right shoulder against Seattle. Staley missed 11 games last season with a foot injury.
Patriots quarterback Drew Bledsoe suffered some internal injuries as a result of a jarring hit in Sunday's game with the New York Jets and could miss at least two weeks of play. Bledsoe was knocked out but did not suffer a concussion, coach Bill Bellichick said. octors inserted a chest tube in Bledsoe, who was expected to remain in the hospital one more day.
Cowboys receiver Raghib Ismail, who already had a career-long 80-yard touchdown catch against San Diego, left in the second quarter with a sprained right knee.
Emmitt Smith, Cowboys, took over the No. 2 spot on the NFL's career rushing list, bypassing Barry Sanders with a 14-yard run just before halftime. With 85 yards Sunday against San Diego, Smith increased his career total to 15,291 yards, still 1,435 yards shy of Walter Payton's record 16,726.