The Buffalo Bills are in the playoffs as one of the three wild-card teams. Who and when they play won't be determined until Sunday, but there are only three possible opponents -- Tennessee, Jacksonville or Seattle -- and it will definitely be on the road.
If the Bills beat the Colts on Sunday, they will clinch the second wild-card spot and play the first wild-card seed -- either Tennessee or Jacksonville.
The Bills will play the Titans in Nashville if the Jaguars win or tie Sunday OR the Titans lose or tie.
The Bills will play the Jaguars in Jacksonville if the Titans win Sunday and the Jaguars lose.
There is only one scenario in which the Bills are the sixth seed and not the fifth seed: if the Bills lose and Seattle and Kansas City both win. In that scenario, Buffalo, Kansas City and Seattle would finish 10-6, but the Seahawks would win the AFC West and the Chiefs would be the second wild-card seed because of a better conference record than the Bills. In that case, the Bills would travel to Seattle.
If the Bills and Seahawks lose and the Chiefs win, KC would win the AFC West and the Bills would still earn the second wild-card spot ahead of Miami and play either Tennessee or Jacksonville.