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Five things to know about the Indianapolis Colts, the Bills' Week 14 opponent

The Indianapolis Colts (3-9, last in AFC South) come to New Era Field in Week 14. Here are five things to know about their matchup with the Bills (6-6):

1. Last game: The Colts got rolled once again, losing 30-10 to Doug Marrone's Jaguars, who look primed for the playoffs at 8-4. It was the Colts' sixth loss in their last seven games after starting 2-3, although their only wins are against the Browns (0-12), 49ers (2-10) and Texans, who were in their first game without hot rookie quarterback Deshaun Watson. The Colts allowed 426 yards of total offense in Sunday's loss, including a 300-yard game to Blake Bortles, whose only other 300-yard game this year came in their first meeting with the Colts. Jacksonville led 16-3 at halftime and the Colts never had the ball with the score closer than three possessions in the second half. T.Y. Hilton scored the Colts' only touchdown on a 40-yard pass in the third quarter.

2. Brissett under center: Bills fans had an early look at Colts quarterback Jacoby Brissett last year when he started for the Patriots in Week 4 while Tom Brady was suspended and Jimmy Garappolo was injured. Brissett was mediocre in the Bills' 16-0 victory, completing 17 of 27 passes for 205 yards, no touchdowns and no interceptions, although that was his second career start. Has Brissett improved since then? He entered Sunday ranked 24th out of 35 qualifying quarterbacks in passer rating (83.1), 27th in completion percentage, 17th in yards and 21st in yards per attempt. Comparatively, Tyrod Taylor ranked 19th, 12th, 24th and 26th. So, Brissett has more volume but less efficiency than Taylor, and doesn't have Taylor's running ability. He might be more comfortable than he was a year ago, but Brissett is a quarterback the Bills should beat.

3. It's a meeting of great backs: Colts running back Frank Gore and Bills running back LeSean McCoy are two of the top backs in league history. Gore is the league’s active leader in rushing yards and moved into fifth place all-time Sunday at 13,697 yards, jumping Jerome Bettis and LaDainian Tomlinson. He is also the active leader in games started by a running back (108), nearly doubling the back in second place, Isaiah Crowell (60). McCoy ranks third on the active list behind Adrian Peterson and moved into 31st place all-time Sunday with 9,805. McCoy spoke glowingly of Gore over the summer, saying older backs often don't get the respect they deserve.

4. Sack attack: The Bills' defensive line has struggled to pressure the quarterback at times this season, but next week could be their best chance to pad their stats. Brissett has been sacked more times than any quarterback in the league by a wide margin. The Jaguars brought him down four times Sunday, bringing his season total to 47. Matt Stafford entered Sunday in second place at 36 (the NFL record is 76 by rookie David Carr for the expansion Texans in 2002).

5. Luck drama: All this talk of Brissett begs the question, where's Andrew Luck? He was thought to be one of the best quarterback prospects in some time when he came out of Stanford in 2012, but injuries have hindered his development. He played only seven games in 2015 due to a shoulder injury and a lacerated kidney. Luck played 15 games in 2016 but couldn't seem to shake another shoulder injury, which required surgery on his labrum after the season. Recovery from that surgery continued into training camp and forced him to open the year on the physically unable to perform list. He returned to practice this fall but had setbacks and was shut down for the year. Luck is expected to return in 2018, but the Colts are also set up for a high draft pick.

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