Chargers OL vs. Bills' DL
The Bills' competition takes a step down after being hammered by the Saints' stellar offensive line. The Chargers' front five has been pretty good in pass blocking but weak in run blocking. Los Angeles has failed to hit 100 rushing yards in six of nine games. Center Spencer Pulley is a weak link and he's bothered by a sore knee. Right guard Kenny Wiggins is a first-time starter at age 29 and has been cut six times in his career, three times by the Chargers. Right tackle Joe Barksdale (foot) may be replaced by weaker Michael Schofield.
Kelvin Benjamin vs. Casey Hayward
Look for the Chargers to have their No. 1 cornerback, Casey Hayward, follow Kelvin Benjamin wherever he goes. Hayward is a former second-round pick who had a breakout season in his fifth year in 2016. He had seven interceptions and a league-high 20 breakups. He only has one pickoff this season but he's tied for fifth in passes defensed (11). The 6-5 Benjamin has a distinct size edge. The 5-11 Hayward has average height and length (30-inch arms) but he has good instincts.
Bills OTs vs. Bosa & Ingram
The Chargers' two elite edge rushers have combined for 36.5 sacks since the start of 2016. Joey Bosa has 9.5 this season. Melvin Ingram has 8.5. They are terrors off the edge and look for them to move around to try to exploit the Bills' pass protection. The Bills must avoid third and long. The Chargers rank 17th overall on third down defense, allowing 40.3 percent conversions. But they're tied for third on third-and-8 or more, allowing just 15 percent conversions. And their 14 sacks on third down ranks second in the NFL in that category.