The Bills scored in the first quarter for the first time all season, but that was about the only thing that went right in the opening 15 minutes.
Bengals star receiver A.J. Green blew past rookie corner Tre'Davious White for an easy, 77-yard touchdown down the sideline on the first play after the Bills went three-and-out on their opening drive. Tight end Charles Clay, the Bills' leading receiver, appeared to suffer a knee injury after a catch later in the quarter and limped gingerly on the sideline before being carted off.
The early 7-0 deficit marked the Bills' largest of the season. They answered with a 31-yard field goal with 10 seconds left in the quarter.
Run game gets going: The Bills gained 38 yards on the ground on seven carries in the first quarter, good for 5.4 yards per rush. They entered the game 27th in the NFL at 3.4 yards per carry. Getting the running game going early was important on a rainy day with top receiver Jordan Matthews out and Clay injured.
Tyrod goes down twice: Vlad Ducasse started at right guard for John Miller and Dion Dawkins was at left tackle for the injured Cordy Glenn. They opened good holes for LeSean McCoy, but allowed two sacks in the first quarter.