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Stats Wizard: All-time numbers in Bills-Panthers series and more

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Bills vs. Panthers: Six games all time.

Bills record: 5-1 (.833).

First game: On Sept. 10, 1995, this was just the Panthers' second game — their first was a 23-20 overtime loss to the Atlanta Falcons. The Bills won, 31-9, scoring 28 points in the third quarter. Only once have the Bills had more points in a quarter, a 34-17 victory over the Chiefs on Sept. 13, 1964, in which they scored 31 points in the first quarter.

The Bills' defense surrendered just 12 passing yards in the Panthers game, fourth fewest in any of their 869 games all time, with their fewest coming Dec. 12, 2004, when the Cleveland Browns, behind Luke McCown, tallied -3 total yards passing.

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Longest Bills winning streak: Three games, from Sept. 10, 1995, to Dec. 9, 2001. The Bills have won their last two games against the Panthers, with their last — a 24-23 victory — coming Sept. 15, 2013.

Longest Bills losing streak: Only lost one game, a 13-9 defeat Nov. 27, 2005.

Most points for: 31, in a 31-8 victory Sept. 10, 1995.

Most points allowed: 24, in a 25-24 victory Dec. 9, 2001.

Biggest win: 23 points, on Sept. 10, 1995.

Biggest loss: Four points — again, their only loss — on Nov. 27, 2005.

All-time Bills leaders against the Panthers

Passing leaders: No Bills quarterback has started multiple games against the Panthers. Among the six who have — Jim Kelly, Doug Flutie, Alex Van Pelt, J.P. Losman, Ryan Fitzpatrick, and EJ Manuel — believe it or not, Manuel leads the way with 296 yards passing, while Flutie is the only with multiple touchdown passes, having thrown two.

Flutie’s rating of 130.1 is also the best among the group and oddly enough, Kelly had the worst game — going 4 for 21 for 176 yards, one touchdown, three interceptions, and a 38.3 rating. To give you an idea of just how bad that is, had he instead gone 0 for 21 with no interceptions, his rating would have been 39.6.

Rushing leaders: Thurman Thomas leads the way with 110 yards rushing and two touchdowns in two total games against the Panthers. C.J. Spiller's 6.4 yards per carry rank first — more on this in the single-game standouts section below.

Receiving leaders: Eric Moulds totaled 16 receptions. His 279 total receiving yards, 17.4 yards per catch and two touchdown catches are also Bills bests against the Panthers.

Special teams leaders: Rian Lindell leads with five field goals made, while Steve Christie leads with seven extra points — giving him a team-best 19 total points, combined with his four field goals . The Bills have never returned a punt or a kick for a touchdown against the Panthers.

Defensive leaders: Paul Posluszny and Kiko Alonso each had nine tackles, both in just one game, and Mario Williams had 4.5 sacks against the Panthers — representing 32.1 percent of all the Bills' sacks against the Panthers. Jarius Byrd leads the way with two interceptions, both in the same game, while Kurt Schulz and Brandon Spoon each had a pick-six.

Bills single-game standouts

Eric Moulds: On Oct. 25, 1998, Moulds had five catches for 145 yards with two touchdowns in a 30-14 victory over Carolina. He is the only Bills player to have multiple touchdowns in a single game against the Panthers.

Doug Flutie: In that same game, Flutie went 18 for 22 with 282 yards passing, two touchdowns — both to Moulds— one interception, and a 130.1 quarterback rating. Flutie, just two days after his 36th birthday, added 27 yards on the ground, including two first downs.

Steve Christie: In that same game, Christie totaled 12 of the Bills' 30 points on three extra points and three field goals, all of which were over 40 yards — 42, 47, and 44 yards. Only three times since has a Bills kicker had three field goals in a game from at least 42 yards out; one of those games was by Dan Carpenter against the Panthers on Sept. 15, 2013, when he made 42-, 55-, and 48-yard field goals.

Alex Van Pelt: On Dec. 9, 2001, Van Pelt went 20 for 29 with 277 yards passing, a touchdown and an interception, and a 96.5 rating. The Bills won, 25-24, in this barnburner — Buffalo entered the game 1-10, Carolina 1-11.

Mario Williams: We already touched on this, but it is certainly worth mentioning again. On Sept. 15, 2013, Mario Williams totaled 4.5 sacks against the Panthers. This stands as a single-game record for the Bills not just against the Panthers, but against any team, besting the old record of 4.0, held by Cornelius Bennett and all-time sack leader Bruce Smith, who did it twice.

Worth noting: there have only been two games since in which a player had at least 4.5 sacks since: the Chiefs' Justin Houston (4.5) on Sept. 19, 2013, and the Raiders' and UB product Khalil Mack (5.0) on Dec. 13, 2015.

C.J. Spiller: On Sept. 15, 2013, Spiller totaled 103 yards on 16 carries, including a long run of 46 yards. He added 14 yards on three catches. He and Travis Henry (in the Dec. 9, 2001 game) are the only Bills to rush for 100 yards in a game against the Panthers. For now …

Sunday’s game: Carolina is a touchdown favorite. I think they will outlast the Bills, but expect LeSean McCoy to get his, helping Buffalo bettors to cover.

Did you know? Carolina quarterback Cam Newton’s father, Cecil Newton Sr., a safety out of Savannah State, played for the Bills in the 1984 preseason before being cut.

On this date: In 1973, O.J. Simpson rushed for a then AFL/NFL single-game record 250 yards, breaking the Bills' Cookie Gilchrist's record of 243 rushing yards Dec. 8, 1963. Simpson would later break his own record, rushing for 273 yards Nov. 25, 1976. Since, this record has exchanged hands four times: Walter Payton (275), Corey Dillon (278), Jamal Lewis (295), and the current record of 296 yards by Adrian Peterson on Nov. 4, 2007.

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