Each week throughout the season, we will examine the most intriguing one-on-one matchups in the Bills' upcoming game, pinpointing the biggest disadvantages and advantages for the Bills, as well as the contest's best individual matchup.
Against the Jets, the focus will be on both sides of the line of scrimmage.
Let's take a look.
(Stats courtesy of Pro Football Focus.)
Bills' biggest disadvantage
RT Jordan Mills vs. Jets DE Muhammad Wilkerson
Wilkerson had a down year in 2016, especially by his standards. It was his first season back from an ACL tear, so there's reason to believe he wasn't 100 percent healthy, but his production dipped nonetheless.
From 2011 to 2015, Wilkerson averaged a little more than eight sacks, nearly 13 quarterback hits and almost 29 quarterback hurries per season, which equates to 50 total QB pressures on an annual basis.
But last year, he only had 30 QB pressures. However, there's no doubting his natural talent and pass-rushing refinement. From his left end spot, he'll see Bills right tackle Jordan Mills often. Mills graded as the 61st-best offensive tackle out of 76 qualifying at his position.
Only four offensive tackles in all of the NFL allowed more than the 57 pressures Mills surrendered in 2016. Buffalo will need a strong game for Mills to keep Wilkerson at bay.
Bills' biggest advantage
DT Kyle Williams vs. Jets C Wesley Johnson
Staying in the trenches, the Bills have an edge on the interior. Last year, Johnson was the No. 32-ranked center by PFF. Meanwhile, Williams had the fifth-highest grade among 3-4 defensive ends – he'll play his usual defensive tackle spot in Sean McDermott's defense.
That means the two will lock horns frequently Sunday. Whenever they do: advantage, Bills.
Best one-on-one matchup
Bills LT Cordy Glenn vs. Jets DE Leonard Williams
Williams emerged as an underrated superstar in 2016 at just 22 years old. Pro Football Focus credited him with eight sacks and 61 total tackles while playing defensive end and some nose tackle. The former USC standout also had 11 quarterback hits and 36 quarterback hurries. His 55 total quarterback pressures (sacks, hits, and hurries) were six more than Bills edge-rusher Lorenzo Alexander had in 2016.
From his right end position, Williams will primarily square off against Bills left tackle Cordy Glenn. Last year, Glenn was a model of consistency in pass protection. He allowed one sack, zero hits, and 16 hurries on 365 pass-blocking snaps. Those 17 total pressures were the third-fewest among 61 qualifying offensive tackles.
He and Williams will make for a superb battle Sunday.