Bills running back LeSean McCoy didn't practice all week after aggravating his hamstring injury in last Sunday's loss at Miami and is officially listed as doubtful to play this week against the Patriots.
"Obviously he never practiced," Rex Ryan said, "so I think you guys can figure that out."
Without McCoy, Mike Gillislee would be in line to start, with Reggie Bush and rookie Jonathan Williams up next. Gillislee is officially listed as questionable with a foot injury, but he says he's fine – his wore a new pair of cleats last week that dug into the back of his foot, and he had to be listed on the injury report because he got treatment from the medical staff to help with the inflammation.
Bills receiver Marquise Goodwin (concussion) and safety Aaron Williams (neck) are out for the game. Receiver Robert Woods (foot) is questionable.
Defensive tackle Marcell Dareus, who plans to make his season debut Sunday, said he feels ready to play an entire game.
"If the Lord wakes me up, I'm playing every play," he said. "I'll play as much as I can if I get up out of bed."
The following players are questionable for the Bills: DL Corbin Bryant (shoulder), TE Charles Clay (ankle), LB Lerentee McCray (knee), DT Marcell Dareus (hamstring), RB Mike Gillislee (foot), LB Jerry Hughes (hand), RG John Miller (shoulder), WR Robert Woods (foot) and LT Cordy Glenn (ankle).