A 42-year-old Lancaster man was killed when his minivan collided with a tractor-trailer before noon Monday on Genesee Street in Lancaster.
Investigators said the minivan, which was heading east, crossed into the opposite lane and collided head-on with the westbound truck.
The minivan driver, whose name has not been released, died at the scene.
The driver of the tractor-trailer, a 35-year-old Buffalo man, was not injured and was cooperating with the investigation, police said.
The crash occurred at about 11:45 a.m. roughly a quarter mile east of Harris Hill Road. Genesee Street was closed in both directions for more than four hours between Harris Hill and Stony roads.
An investigation into the cause of the crash is ongoing.