The Buffalo Bills will be without starting right tackle Seantrel Henderson again. The second-year pro is inactive with an illness even though he was listed as probable heading into the game. Jordan Mills will start in his place.
They do get rookie right guard John Miller back from his high ankle sprain.
On the other sideline, the Philadelphia Eagles have activated all four running backs. Chip Kelly is dressing Ryan Mathews, Darren Sproles, DeMarco Murray and Kenjon Barner though Murray will reportedly be the fourth-string back. Quite a fall from grace for the high-price back Kelly's Eagles signed to replace LeSean McCoy.
Leodis McKelvin will start at cornerback in place of Stephon Gilmore (shoulder), while Kevin Reddick will start in place of Nigel Bradham (ankle) at inside linebacker.
Here are the full inactives...
Buffalo Bills: LB Nigel Bradham, CB Ron Brooks, CB Stephon Gilmore, OT Seantrel Henderson, QB Josh Johnson, DE Lavar Edwards.
Philadelphia Eagles: QB ThadLewis, WR Jonathan Krause, CB Denzel Rice, LB Steven Means, OL Barrett Jones, OL Tanner Hawkinson, DE Brandon Bair.