The Buffalo Bills' injury report had a high-profile addition Thursday.
Running back LeSean McCoy left practice Thursday after experiencing "tightness" in his hamstring, according to coach Rex Ryan.
"I know the first thing is going to be, whoa, whoa, whoa, what's up with McCoy's hamstring," Ryan said. "It was a little tight, a little sore, so I think that's where it is. Do I expect him to play? I certainly hope so. He just felt sore, so we backed him out."
McCoy initially suffered a hamstring injury almost exactly a month ago, during an Aug. 18 night practice with the Cleveland Browns. He sat out the final three preseason games, but got a steady workload in the season opener. He carried the ball 17 times for 41 yards and also caught three passes for 46 yards in playing 71 percent of the Bills' offensive snaps.
Ryan said that Karlos Williams would replace McCoy in the lineup, but "I don't even want to think that way. ... I'm not giving up on McCoy."
Williams said he didn't even notice during practice that McCoy had left.
"We get so many reps, and the ball moves so fast around, so much going on, we really try to pay attention to the plays and get those mental reps, so really did not notice that he wasn't out there," he said. "I hope he's back, I hope he can play. If he's not, then I'll be ready to play."
Williams said he's 100 percent recovered from an undisclosed surgery he had that took him out of the final three preseason games. If he does have to step in for McCoy, his role will not only involve more carries, but also blocking and receiving.
"Been doing that since the day I got here," he said. "It's very key for this offense that the back can protect, the back can catch the ball out of the backfield, so if my number's called, I'm definitely ready."