Buffalo Bills quarterback EJ Manuel (3) falls out of bounds at FirstEnergy Stadium in Cleveland,Ohio on Thursday, Oct. 3, 2013. Manuel was injured on the play. (James P. McCoy/ Buffalo News)
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Tashaun Gipson took out EJ Manuel with a low hit Thursday night in FirstEnergy Stadium.

The Buffalo Bills announced Manuel’s right knee is sprained. We don’t yet know how serious the injury is, but Manuel’s absence for much of the second half surely helped send Buffalo to its doom, a 37-24 loss.

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