Clarence coach Tom Goddard's 100th win came at a nice time.
The Red Devils head into the playoffs with some good momentum after going on the road to hand Iroquois its first loss, 32-17.
The Red Devils (4-3) were unranked while pollsters had Iroquois (6-1) fourth among large schools.
"It's a great win to get our spirit going again and to get ready for North Tonawanda," said Goddard, who is in his 16th season.
Clarence bounced back after losing a big lead at home to Jamestown last week.
"[Iroquois] got a score just before halftime -- we snapped a ball over our punter's head, and they took it right in so they were up, 14-12, at halftime," said Goddard. "We came out, got the ball on the opening kickoff and stuck it right in and kept going from there. The kids played extremely well. In the second half we shut them down except for that field goal."