Rudi Johnson, Bengals, ran for a season-high 202 yards and two scores on 26 carries in a 58-48 win over Cleveland.
Willis McGahee, Bills, had 116 yards and four touchdowns on 28 carries in a 38-9 win over Seattle.
Domanick Davis, Texans, rushed for a season-high 129 yards, including a 41-yard touchdown run, in a 31-21 win over the Titans. Davis added seven receptions for 52 yards.
Fred Taylor, Jaguars, had 147 yards on 22 carries in a 27-16 loss to Minnesota.
Corey Dillon, Patriots, rushed for 123 yards and a touchdown in a 24-3 win over Baltimore.
Nick Goings, Panthers, ran for 106 yards in a 21-14 win over Tampa Bay, a week after rushing for a career-high 121.
Drew Brees, Chargers, completed 28 of 37 passes for 378 yards and two touchdowns in a 34-31 win over Kansas City.
Kelly Holcomb, Browns, went 30 for 39 for 412 yards, the second-most yards in his career, and five touchdowns in a 58-48 loss to Cincinnati. Carson Palmer, Bengals, threw a career-high four touchdown passes and finished 22 of 29 for 251 yards.
Brian Griese, Bucs, went 27 of 39 for 347 yards, two touchdowns and an interception in a 21-14 loss to Carolina.
Chad Johnson, Bengals, had 117 yards and a touchdown on 10 receptions in a 58-48 win over Cleveland.
Keary Colbert, Panthers caught a 40-yard touchdown pass, his second of the game, with 20 seconds remaining to lift Carolina to a 21-14 victory over the Bucs. Colbert finished with 72 yards on three catches.
Michael Pittman, Bucs, had eight catches for 134 yards and touchdown receptions of 6 and 8 yards in a 21-14 loss to Carolina. Pittman, the starting running back, only had 29 yards rushing on 18 carries.
Antonio Gates, Chargers, had seven catches for 92 yards and two touchdowns in a 34-31 win over Kansas City.
Alge Crumpler, Falcons, had four catches for 103 yards and the game-winning 20-yard scoring reception in a 24-21 win over New Orleans.
The Philadelphia Eagles are the third team since the 16-game schedule began in 1978 to win a division title by its 11th game, joining the Bears in 1985 and the 49ers in 1997. Chicago won the Super Bowl after the 1985 season.
Adam Vinatieri's 28-yard field goal early in the second quarter put New England up, 3-0, and gave the Patriots an NFL record with 16 consecutive regular-season games in which they've scored first. The Miami Dolphins set the record of 15 straight in 1978.
Jerome Bettis' 47th career 100-yard game matches Franco Harris' Steelers team record.
Andy Reid won his 66th game, tying him with Greasy Neale for No. 1 among Eagles coaches.
Antonio Gates had two touchdown receptions to give him 11 on the season, breaking Kellen Winslow's record for San Diego tight ends.
The Steelers' nine-game winning streak is their longest since they won their final nine in 1976. They are 10-1 for the first time since 1975, the second of their four Super Bowl championship seasons.
The Texans ended a three-game losing streak and, perhaps most importantly to their fans, swept the season series from the team they replaced in Houston. They also tied their win total from last season.
The Panthers have won three straight after losing six in a row.
Miami (2-9) snapped its three-game losing streak with just 200 total yards, while the 49ers (1-10) lost their sixth straight and allowed eight sacks. San Francisco has a shot at the worst record in franchise history: the Niners went 2-14 in 1978 and 1979.
Tom Brady's streak of 16 games with a touchdown pass for New England, including playoffs, was snapped by Baltimore.
Kyle Boller's streak of 123 passes without an interception ended with New England's Randall Gay's pickoff midway through the second quarter against the Ravens.
Emmitt Smith was knocked out of the game against the New York Jets with a toe injury on his left foot. The Cardinals running back went to the turf in obvious pain after a 6-yard run in the first quarter. Smith, the NFL's career rushing leader with more 18,000 yards in 15 seasons, had been slowed by a left ankle injury the last two weeks.
Jets QB Quincy Carter was briefly knocked out with a head injury, but returned to lead the 13-3 victory.
Steelers running back Duce Staley unexpectedly sat out a fourth straight game with a sore hamstring.
Chiefs safety Greg Wesley injured his hamstring during pregame warmups and was replaced by Willie Pile.
Randy Moss had four receptions -- his first in six weeks -- for 40 yards and a touchdown in the Vikings' 27-16 win over Jacksonville. For the first time since he got tangled up with a defender in the second quarter of the Oct. 17 game at New Orleans and partially tore his right hamstring, Moss was running around without a limp.
Giants rookie QB Eli Manning finished 6 of 21 for 148 yards and two critical interceptions in a loss to Philadelphia. He was also sacked five times.