Marcus Price may make his third start of the season Sunday in place of right tackle Mike Williams.
Williams, who suffered a scary collision in the win over the New York Jets on Sunday, did not practice Wednesday and is listed as questionable for Sunday night's game in New England.
Williams said he was feeling much better Wednesday but still had a stiff neck.
Coach Mike Mularkey said all tests on Williams' head and neck came back negative.
"He went through the walk-through segment of practice, and we wanted to just loosen him up a little bit in the pool and give him a day to make sure everything is looser," Mularkey said. "I know he's sore. . . . Tests were fine. No nausea, no concussion, just a sore neck."
Besides cornerback Troy Vincent (knee), who is listed as questionable, the Bills have three players on the injury report. Receiver Josh Reed (knee) and safety Coy Wire (abdomen) are doubtful. Defensive end Constantin Ritzmann (foot) is out.
Rookie quarterback J.P. Losman took a few snaps with the Bills' offense, not just with the scout teams. The Bills still are taking it slow with his recovery from a broken leg.
"It's a very gradual introduction for him," Mularkey said.
The Pats remain depleted at cornerback, with starters Ty Law (foot) and Tyrone Poole (knee) out. Backup receiver Deion Branch (knee) and backup linebacker Matt Chatham (hamstring) are questionable.
When the Bills met the Pats on Oct. 3, Bills tackle Jonas Jennings was knocked out in the third quarter on a hit from Pats defensive tackle Vince Wilfork. The Pats rookie caused what looked like an unnecessary collision in the backfield well after a pass had been released. Jennings wasn't happy about it at the time but wasn't making a big deal of it Wednesday.
"I don't think it was necessary, but at the same time I don't worry about it," he said. "I don't worry about what I can't control. Whether it was necessary or not, it was done. It's all on the up and up, and you can't worry about the negative.
"He's not a guy I really see down to down. But it's something to look at. He knows we know. It's nothing you actually try to use (for motivation). I got caught in a bad situation, he took advantage of it. That's football."
The Bills opted to use rookie Freddie Smith as the No. 3 receiver most of the time against the Jets instead of second-year man Sam Aiken. Mularkey said they wanted Smith working out of the slot.
"It's just different kinds of receivers," he said. "Some guys are better inside when you go to specific personnel groupings or formations and some guys are better outside."