Drew Bledsoe, Patriots, threw four touchdown passes as New England rallied from a 28-7 deficit to defeat Arizona, 31-28.
Neil O'Donnell, Titans, completed 31 of 40 passes for 310 yards and a touchdown in Tennessee's 26-9 victory over Cleveland.
Randall Cunningham, Vikings, completed 23 of 39 passes for 364 yards in Minnesota's 22-17 loss to Oakland.
Kimble Anders, Chiefs, gained a career-high 142 yards before he was injured on his last carry of Kansas City's 26-10 upset of Denver.
Stephen Davis, Redskins, ran for 126 yards and three first-half touchdowns in Washington's 50-21 rout of the New York Giants.
James Stewart, Jaguars, rushed for 124 yards and two TDs, including a 44-yarder with 1:48 left, in Jacksonville's 22-20 victory over Carolina.
Dorsey Levens, Packers, rushed for 153 yards in Green Bay's 23-15 loss at Detroit.
Derrick Mayes, Seahawks, caught seven passes for 137 yards, including a 34-yard touchdown reception, in Seattle's 14-13 victory over Chicago.
Jimmy Smith, Jaguars, caught 10 passes for 115 yards, in Jacksonville's win.
Terry Glenn, Patriots, caught seven passes for 122 yards in New England's win.
Olindo Mare, Dolphins, kicked four field goals -- from 39, a career-best 51, 48 and 44 yards -- in Miami's 19-16 victory over Arizona.
Adam Vinatieri, Patriots, kicked a 26-yard field goal with 35 seconds left to give New England the victory over Indianapolis. It was Vinatieri's second final-minute, game-winning field goal in the first two weeks of the season.
Tampa Bay recorded nine sacks in a 19-5 victory over Philadelphia, including 3 1/2 by Warren Sapp. . . . Russell Maryland recovered a fumble and intercepted a pass, leading an Oakland defense that had six sacks and held Minnesota to 34 yards rushing in beating the Vikings. . . . Pittsburgh RB Jerome Bettis gained 46 yards and passed John Henry Johnson for second place on the Steelers' career rushing list, behind Franco Harris. . . . Chicago's six sacks against the Seattle Seahawks were its most since 1993, when it recorded seven against Philadelphia. . . . Denver tight end Shannon Sharpe caught six passes for 52 yards, giving him 6,858 yards receiving for the Broncos. He needs 15 yards to pass Lionel Taylor for the team record. . . . The Tennessee Titans are the first NFL team to record safeties in back-to-back games since the Kansas City Chiefs did it in 1997.
Cincinnati QB Jeff Blake left with a sprained shoulder after he was hit by San Diego linebacker Junior Seau, causing a fumble late in the first half. Gerald Dixon returned the ball 27 yards for a touchdown and a 28-7 lead for the Chargers on the way to a 34-7 victory. . . . Jacksonville's Mike Logan, a kick returner and reserve safety, fractured his left ankle while running back a kick in the second quarter.
San Francisco picked up a key first down in the first half against New Orleans on Charlie Garner's 11-yard run after scooping the ball off Steve Young's chest when the 49ers quarterback tripped and fell backpedaling from center. . . . Eagles kicker Norm Johnson was late getting on the field and missed a 26-yard field-goal attempt as time expired in the first half.
Jake Plummer completed just 11 of 27 passes for 112 yards, and was intercepted four times in Arizona's loss to Miami. Plummer has been intercepted seven times in two games. . . . Cincinnati fumbled seven times in its loss to San Diego, losing four of them. . . . Baltimore QB Scott Mitchell, benched in Detroit last year after just two games, was pulled after going 7 for 16 for 48 yards and two interceptions in the Ravens' 23-20 loss to Pittsburgh. He was coming off a 17 for 40 effort in the opener. . . . Cleveland QB Tim Couch had a rough time in his first NFL start, getting sacked seven times and completing only 12 of 24 passes for 134 yards in a 26-9 loss to Tennessee. . . . Cincinnati QB Akili Smith, who missed most of training camp in a contract dispute, led the Bengals offense to two first downs and 21 net yards in the second half after replacing injured starter Blake.
Only 47,660 fans at Cinergy Field saw the most lopsided home-opening loss in Bengals' history.