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Roswell Park Cancer Institute is looking for people to join a study on a new drug that may prevent some types of cancer.

Male and female volunteers, ages 18 to 75, are needed. Persons with a precancerous condition that puts them at increased risk of developing cancer of the colon will be given priority. Also needed are persons who have undergone potentially curative surgery, but who are at high risk for recurrence, including those who have had surgery for lung cancer and breast cancer.

The drug being tested, dufluoromethylornithin, has shown promise in altering the makeup and stopping the development of cells that lead to cancers. It will be administered orally four times a day for six months. Patients will be monitored for toxicity and will undergo monthly blood tests, chest X-rays, urinalysis and EKGs.

Two overnight hospital stays -- at the beginning of treatment and again at the end -- may be necessary. Persons who complete the six-month treatment course will be tested again after three months to assess the long-term effects of the drug.

Those interested in volunteering should contact Roswell Park's Division of Clinical Pharmacology and Therapeutics at 845-5721, Monday through Friday during business hours.

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